Not if you're drunk, tired, pregnant or a child.  http://www.cbc.ca/health/story/2010/04/22/tv-3d-children-health.html, http://www.networkworld.com/news/2010/041310-3d-tv-not-for-the.html?hpg1=bn and http://www.gamesradar.com/f/bad-news-for-drunks-you-cant-play-3d-tv/a-2010041415350994080
Would warnings from TV Manufacturers prevent you from enjoying your 3D big screen after a few beers?  Personally, that's when I think playing a little Gran Turismo would be most interesting!  (Fun for others to watch, anyway)